Mitigating Immune-Mediated Diseases Linked to Climate Change: Goals, Challenges, and Investment Needs for 2050

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation
Agache, I., Akdis, C., Akdis, M., Balmes, J., Cecchi, L., Damialis, A., Haahtela, T., Haber, A. L., Hart, J. E., Jutel, M., Mitamura, Y., Mmbaga, B. T., Oh, J., Ostadtaghizadeh, A., Pawankar, R., Prunicki, M., Renz, H., Rice, M. B., Filho, N. A., . . . Nadeau, K. C. (2024). Immune-mediated disease caused by climate change-associated environmental hazards: Mitigation and adaptation. Frontiers in Science, 2, 1279192. https://doi.org/10.3389/fsci.2024.1279192

Introduction

Climate change represents one of the most complex and pervasive crises humanity has ever faced. The environmental hazards caused by climate change—including air pollution, rising temperatures, wildfires, floods, dust storms, and biodiversity loss—directly affect human health, particularly the immune system’s function. Immune dysregulation triggered by climate-induced stressors leads to an increase in immune-mediated diseases such as asthma, allergies, autoimmune disorders, and cancers.

This document focuses on the goals necessary to mitigate the impact of climate change and implement adaptation measures to protect public health. It also explores the contradictions that hinder effective action and sustainability, providing a detailed analysis of the investment requirements necessary to address climate change and alleviate immune-mediated diseases.

Goals

The mitigation and adaptation measures required to address climate change and reduce immune-mediated diseases revolve around several central goals:

1. Net-Zero Emissions by 2050 (CO2 = 0)

  • Stopping Climate Change: Achieving net-zero carbon emissions by 2050 is critical to prevent the global temperature from rising beyond 1.5°C.
  • Decarbonization Measures: The shift to renewable energy sources like solar and wind power, as well as the adoption of carbon-neutral technologies in energy production and industry, are essential steps. Countries must invest in new energy infrastructure to meet this target.
  • Investments: According to the UN, an estimated $1.8 trillion annually in global investments is required to reach net-zero emissions by 2050 and avoid catastrophic climate impacts.

2. Biodiversity Protection and Restoration

  • Preserving Ecosystems: The goal is to protect and restore biodiversity, including forests, wetlands, and grasslands, which play a crucial role in climate stabilization and human health.
  • Forest Restoration and Conservation: The IPCC estimates that $500 billion per year is needed for reforestation and biodiversity preservation until 2030 to ensure a sustainable climate and prevent ecosystem collapse.
  • Health Impacts: Maintaining biodiversity reduces zoonotic disease transmission and supports ecological balance, which in turn helps protect the immune system’s functioning.

3. Sustainable Food Systems and Agricultural Practices

  • Sustainable Agriculture: The transformation of food production systems involves reducing the use of chemical fertilizers and pesticides, promoting regenerative agriculture, and integrating livestock into holistic farming practices.
  • Investments in Sustainable Food Systems: The FAO estimates that $300–350 billion annually is needed to reform agricultural practices and establish sustainable food systems by 2050. This investment reduces the carbon footprint of agriculture and safeguards human health from exposure to harmful chemicals.
  • Healthier Diets: Shifting agricultural practices and promoting plant-based diets are linked to stronger immune systems and lower incidences of chronic diseases.

4. Urban Adaptation and Green Space Expansion

  • Sustainable Cities: Expanding green spaces and adapting cities to the impacts of climate change, including heatwaves and floods, is essential to improve urban living conditions and protect people from environmental hazards.
  • Investments in Urban Adaptation: Globally, an estimated $100 billion annually is required to adapt cities and expand green spaces. These investments aim to increase the resilience of urban areas, including flood-proof infrastructure and improved water management systems.
  • Health Benefits: Expanding urban green spaces can reduce air pollution, provide healthier environments, and lower the incidence of respiratory and immune-mediated diseases.

Contradictions

Despite the established goals for mitigating climate change and adapting to its health impacts, several contradictions arise, complicating the implementation of these solutions. These contradictions involve economic, social, and environmental trade-offs.

1. Economic Growth vs. Climate Change Mitigation

A significant contradiction exists between the need for climate action (e.g., reducing CO2 emissions to net-zero by 2050) and the ongoing reliance on economic growth, often driven by high-carbon sectors such as industry, transport, and agriculture.

  • Contradiction: Economic growth, especially in many developing countries, remains heavily dependent on fossil fuels. Achieving net-zero emissions would require massive restructuring of industrial and energy sectors, potentially stifling economic growth.
  • Health Impact: While reducing carbon emissions could improve health outcomes by reducing pollution-related diseases, economic downturns triggered by this transition may limit the ability to fund public health systems, exacerbating health disparities.

2. Developing vs. Developed Nations

Another major contradiction lies in the disparity between the ability of developed and developing countries to implement climate change mitigation and adaptation strategies. Developing countries face the greatest health impacts from climate change but have the least resources to address them.

  • Contradiction: Developed countries, historically responsible for the bulk of greenhouse gas emissions, have more resources to invest in climate resilience and healthcare. Developing nations, despite contributing less to climate change, are disproportionately affected and lack sufficient funding for mitigation.
  • Health Impact: The unequal distribution of resources exacerbates global health inequities, as developing nations experience higher rates of climate-related illnesses, such as respiratory diseases and infectious diseases, but lack adequate healthcare infrastructure to address these crises.

3. Sustainable Agriculture vs. Food Security

Intensive agriculture, characterized by high yields and heavy use of chemical inputs, is crucial to meeting the world’s growing food demand. However, it is also responsible for significant environmental degradation, contributing to climate change and immune system dysregulation.

  • Contradiction: While sustainable agricultural practices reduce environmental impact and improve long-term health, they may initially result in lower food production, creating concerns about global food security.
  • Health Impact: Reducing the use of chemical fertilizers and pesticides would protect the immune system from harmful substances linked to autoimmune diseases and allergies. However, insufficient food production could lead to malnutrition, particularly in low-income regions.

4. Green Energy Transition and Social Justice

The transition to renewable energy and achieving carbon neutrality may result in social and economic challenges, particularly if not managed equitably.

  • Contradiction: The transition to renewable energy, while essential for reducing carbon emissions, may disproportionately affect lower-income populations. Energy prices could rise during the transition, and fossil fuel-dependent regions could experience widespread job losses.
  • Health Impact: Economic inequality exacerbated by rising energy costs may limit access to healthcare for vulnerable populations. Additionally, job losses in fossil fuel industries could reduce household incomes, further hindering access to medical care and exacerbating health disparities.

5. Technological Solutions vs. Natural Solutions

While technological innovations, such as carbon capture and storage (CCS), are seen as critical to reducing atmospheric CO2 levels, there is skepticism about their long-term efficacy compared to nature-based solutions such as reforestation and ecosystem restoration.

  • Contradiction: Technological solutions can be expensive, experimental, and difficult to scale, whereas natural solutions are proven to enhance climate resilience but require more time to take effect.
  • Health Impact: If technological solutions fail to deliver the expected carbon reductions, continued exposure to high pollution levels could exacerbate chronic illnesses such as asthma, autoimmune diseases, and cancer.

Investments in Numerical Terms

Significant investments are required to meet the goals for climate change mitigation and adaptation. The following are the investment estimates necessary to achieve the outlined goals:

  1. Net-Zero Emissions by 2050: The UN estimates that $1.8 trillion annually is needed globally to achieve net-zero carbon emissions by 2050.
  2. Biodiversity Protection and Restoration: The IPCC estimates that $500 billion per year is necessary to restore ecosystems and protect biodiversity, preventing ecological collapse and its associated health impacts.
  3. Sustainable Food Systems: The FAO projects that $300–350 billion annually will be required to implement sustainable agricultural practices by 2050.
  4. Urban Adaptation and Green Space Expansion: Urban resilience efforts, including flood-proof infrastructure and expanded green spaces, require an estimated $100 billion annually on a global scale.

Conclusion

Mitigating immune-mediated diseases caused by climate change and its environmental hazards demands coordinated global efforts and substantial investments. While the goals of reducing carbon emissions, protecting biodiversity, implementing sustainable agricultural practices, and adapting cities to climate impacts are clear, significant contradictions arise between economic development, social equity, and environmental sustainability. Achieving these goals will require addressing these contradictions through international cooperation, policy reforms, and equitable investment in public health and climate resilience. Investing in these initiatives is not only crucial for protecting the planet but also for safeguarding human health and reducing the burden of immune-mediated diseases in a changing climate.

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation
Agache, I., Akdis, C., Akdis, M., Balmes, J., Cecchi, L., Damialis, A., Haahtela, T., Haber, A. L., Hart, J. E., Jutel, M., Mitamura, Y., Mmbaga, B. T., Oh, J., Ostadtaghizadeh, A., Pawankar, R., Prunicki, M., Renz, H., Rice, M. B., Filho, N. A., . . . Nadeau, K. C. (2024). Immune-mediated disease caused by climate change-associated environmental hazards: Mitigation and adaptation. Frontiers in Science, 2, 1279192. https://doi.org/10.3389/fsci.2024.1279192
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